Agilent’s innovation in autosampler technology shines through its Hybrid Multisampler Series, comprising the 1260 Infinity III and 1290 Infinity III Hybrid Multisamplers featuring dual injection modes.

In classic flow-through mode, the mobile phase flows through a preloaded sample loop, as in traditional injection systems. The distinguishing capability, however, is Agilent Feed Injection mode: here, the sample is continuously infused directly into the mobile phase, mitigating issues from strong solvent effects (like peak distortion) by mixing sample and mobile phase at injection time.

This hybrid technology is particularly valuable when analyzing samples in strong solvents—a common challenge in pesticide analysis, PFAS detection, and battery electrolyte characterization. Both the 1260 Infinity II Hybrid Multisampler and 1290 Infinity III Hybrid Multisampler support this mode and assist in preserving peak shape and sensitivity without extra sample prep. If you need any information on this article-related topic, click here. agilent lc autosampler

Particularly in PFAS quantification workflows, Agilent’s Feed Injection improves results: application notes showcase the Hybrid Multisampler’s ability to enhance quantification of trace contaminants and manage challenging sample matrices—again, all without elaborate preparation steps.

In sum, Agilent’s Hybrid Multisamplers embody modern autosampler design by combining flexible injection modes, high capacity, low carryover, and thermal control—making them ideal for ultra-trace, high-throughput, and complex sample analysis.